The principle here is simple: if a plant/fungus can’t run away from you, it’s definitely going to contain defense chemicals, and be net negative for humans.
Most mushrooms people eat like the white button, portobello and cremini varieties, are all from the same fungi, Agaricus bisporus.
This species of mushroom produces a mycotoxin known as agaritine, which is known to be harmful to humans for it binds to DNA, and causes various forms of cancer in animals..
This can be partially solved via cooking, but I don’t believe it’s worth the risk.
Think about it: fungi don’t want to be eaten, just like plants (or animals, but animals can run away/bite, etc.). hey are definitely going to contain defense chemicals!
Sure, they may also contain compounds useful as “medicines”, but MUCH more research is needed before we declare mushrooms a “superfood” and drink them in our morning coffee (also BS!).
I strongly believe there are NO essential compounds found in mushrooms that you can’t get from organs/meat/fruit, etc.
Anecdotally, mushrooms (like lion’s mane, chaga, and reishi) caused one of the worst eczema flares of my life during my residency. This doesn’t mean they will do the same to you, but they clearly contain defense chemicals, oxalates, etc.
I talk more about mushrooms in this episode of Fundamental Health.